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The Truth about Aspartame

Skeptoid #127
November 11, 2008
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As a kid I remember hearing that the artificial sweetener aspartame would neutralize your digestive enzymes, and anything else you ate that day would turn to fat. Although this makes no sense biochemically at any level, it sounded scientific enough to me and I was satisfied with it — at least enough to justify my dislike for its awful flavor. It turns out that my fat-producing claim was about the mildest of many arguments made by a growing anti-aspartame movement, and biochemically-nonsensical as it was, it was among the sanest of the arguments. Take a look at websites such as AspartameKills.com, SweetPoison.com, and Dark-Truth.org, and you'll see that a whole new breed of aspartame opponents has taken activism to a whole new level. Here are a few quotes from those web sites:

Thank you Montel Williams for having the fortitude to say: "Multiple Sclerosis is often misdiagnosed, and that it could be aspartame poisoning"

NutraSweet® killed my mother and has killed and/or wounded millions of innocent people in the US and abroad.

Aspartame converts to formaldehyde in vivo in the bodies of laboratory rats.

ARTIFICIAL SWEETENER, ASPARTAME, (EQUAL, NUTRASWEET) LINKED TO BREAST CANCER AND GULF WAR SYNDROME.

Did O J Simpson Have a Reaction to Aspartame that led to the deaths of Nicole Simpson and Ron Goldman?

THE FDA, THE INTERNATIONAL FOOD INFORMATION COUNCIL (IFIC), PUBLIC VOICE AND OTHERS ARE SCAM NON-PROFIT ORGANIZATIONS AND PAWNS OF THE NUTRA-SWEET COMPANY.

After more than twenty years of aspartame use, the number of its victims is rapidly piling up, and people are figuring out for themselves that aspartame is at the root of their health problems. Patients are teaching their doctors about this nutritional peril, and they are healing themselves with little to no support from traditional medicine.

Donald Rumsfeld disregarded safety issues and used his political muscle to get Aspartame approved.

The Nazi Scientist's Poison Projects: Poison adults with Aspartame

Because of your and/or your forbearers [sic] exposure to toxics like Aspartame, a summation of immune, mitochondrial, DNA, and MtDNA (genetic) damage has occurred in your body that has made your body unable to deal with chemical insults.

The doctor that was in charge of the lab to study Aspartame, reported that the substance was too toxic and he mysteriously dissappeared [sic] and all the paper work somehow was destroyed.

The Nazis actually won the war. They just pretended to lose so that we wouldn't notice them take over our government.

Well, that's enough for now. And if you haven't heard those, you've almost certainly received one of several hoax emails that people have been forwarding around since 1995, according to Snopes.com, giving an equally long list of untrue claims about aspartame being the cause of nearly every illness. One is even falsely attributed to Dr. Dean Edell. Suffice it to say that every possible kind of attack is made against aspartame: Pseudoscientific attacks where they throw out whole dictionaries of scientific sounding nonsense; guilt by association attacks where they mention aspartame alongside Adolf Hitler and Donald Rumsfeld; non-sequiturs like pointing out the evils of the corporate structure of pharmaceutical companies as if that is support for how and why an "aspartame detoxification" program will "heal" you of all disease; and even Bible quotations attacking aspartame. The anti-aspartame lobby appears to include everyone from alternative treatment vendors trying to sell their products, to fully delusional conspiracy theorists. Dr. Russell Blaylock, a retired surgeon turned anti-pharmaceutical author and activist, believes aspartame is part of a massive government mind-control plot:

We're developing a society because of all these different toxins known to affect brain function. We're seeing a society that not only has a lot more people of lower IQ, but a lot fewer people of higher IQ. In other words a dumbing down, a chemical dumbing down, of society. ...That leaves them dependent on government because they can't excel. ...So, you know, you can kind of piece it together as to why they are so insistent on spending so many hundreds of millions of dollars of propaganda money to dumb down society.

Discovered in 1965 at Searle (now Pfizer), aspartame is an artificial sweetener, aspartyl-phenylalanine-1-methyl ester. Chemistry types call it a methyl ester of the dipeptide of the amino acids aspartic acid and phenylalanine. It is 180 times as sweet as sugar, which is why it's such an effective low-calorie sweetener: It's needed in only miniscule amounts. Partly in response to all the anti-aspartame craziness out there, a group of scientists from the NutraSweet company published a 2002 review of dozens of studies and clinical trials performed worldwide in the journal Regulatory Toxicology and Pharmacology, which made the following conclusions:

Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. ...Several scientific issues continued to be raised after approval, largely as a concern for theoretical toxicity from its metabolic components — the amino acids, aspartate and phenylalanine, and methanol — even though dietary exposure to these components is much greater than from aspartame. Nonetheless, additional research, including evaluations of possible associations between aspartame and headaches, seizures, behavior, cognition, and mood as well as allergic-type reactions and use by potentially sensitive subpopulations, has continued after approval. ...The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive. When all the research on aspartame is examined as a whole, it is clear that aspartame is safe, and there are no unresolved questions regarding its safety under conditions of intended use.

And yet the claims persist unabated. Here are a few more, addressed point-by-point:

When you hear claims that are supported only by a fringe minority that's in opposition to the scientific consensus, you have good reason to be skeptical right off the bat, but it doesn't mean it's not worth looking into. Aspartame has been looked into ad nauseum even after its approval, and found safe at every try; so at some point you have to depart from rationality to continue supporting the claims made against it. Enjoy your diet Dr. Pepper, it's not going to hurt you; if it was, I'd have been dead decades ago.

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Brian Dunning
Brian Dunning

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5 most recent comments | Show all 38 comments

Remember, you should always read with skepticism the comments of anyone too lame to put their real name & city.

I recently heard "aspartame poisoning misdiagnosed as MS" twisted into "evidence shows aspartame causes MS". Fear-mongering.

Sam, Destin, FL
December 01, 2008 6:23pm

all i know is that within 15 minutes of ingesting nutrasweet or it's namesakes, i get a migraine for 2-3 days. i eliminate it...no migraines. i never put it together until my dad and i were talking one day. neither of us were diet soda drinkers. my stepmother always kept diet soda around for herself. occaisionally when dad would run out of his he would drink her diet. he said he was getting a lot of bad headaches recently and suddenly they stopped for a one month period while my stepmother was in the hospital. he was doing the shopping and never had any of her diet soda in the house. when he quit drinking it alltogether he had no headaches. within a few days of her return she had gone to the store and stocked up. when he drank the first one he a had a severe headache shortly after. myself, i had recently begun dating a diet soda drinker and was occaisionally drinking one here and there. at dad's idea i quit driking them and my migraines vanished as well. we have both tested this afterward only to become convinced. now, my father and i are both college educated, rational thinkers, not prone to placebo effects. and if it barks like a dog...well. besides this stuff really tastes like crap anyway.

kim, hilton head, sc
December 01, 2008 11:04pm

Brian said: "...a group of scientists from the NutraSweet company published a 2002 review of dozens of studies and clinical trials performed worldwide in the journal Regulatory Toxicology and Pharmacology, which made the following conclusions:", then the conclusions, which are that it's harmless.

I don't believe that aspartame is necessarily dangerous...but this is a case of the alleged perpetrator finding itself innocent. One should be very skeptical of that study, and instead seek studies by disinterested third parties. A real skeptic is universally, not selectively, skeptical.

Personally, I think you should avoid aspartame because it tastes awful and leaves a nasty aftertaste in your mouth. If you need artificial sweetener, then get out of the habit of eating so many sweets.

Paul, Walnut Creek, CA
December 27, 2008 11:49pm

The side-effects of Aspartame reported to the FDA (Food and Drug Administration) is pretty long by all standards, so this chemical is obviously something to avoid, as it's popping up in an ever increasing number of products.

Russell Blaylocks research on Aspartame is still not disputed or countered as far as I know.

Ron, Washington, DC
December 28, 2008 3:13pm

I have been drinking coffee with Equal for as long as I can remember and the same goes for diet soft drinks. My family has been doing much of the same for many years. NONE of us have had any negative effects that can be correlated with aspartame any more than many other possible causes. This DOES NOT mean that aspartame is safe NOR that it is unsafe.

A few posters above have said that they or someone they know have experienced headaches after consuming “diet soft drinks” and they feel this is good reason not to drink them. PERFECT, don’t drink them and do not link aspartame to any generic “diet soft drink” as there are different artificial sweeteners being used in different diet drinks.

OUR PERSONAL EXPERIENCES ARE BIASED AND NOT PART OF A DOUBLE BLINDED CONTROLED STUDY WITH PUBLISHED RESULTS IN A MAJOR PEER REVIEW SCIENTIFIC JOURNAL.

I eat rather healthy most of the time but when I splurge on some fast food, the next day I feel tired and bloated. Does that mean that all fast food restaurants sell unsafe products? NO.

MAX posted a link to an article study the effects of aspartame on energy regulation in rats.
http://www.apa.org/journals/releases/bne-feb08-swithers.pdf
Unless I missed it somewhere, this study said nothing about the safety of aspartame. Even if you look only to the extract at the beginning of the report you can see that their results basically said the rats just got fatter and made no remarks about safety.

Bill Petry, St Peters
January 04, 2009 6:19pm

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