Genetically Modified Organisms: Jeopardy or Jackpot?

Are GMO crops dangerous, or a boon to mankind?

by Brian Dunning

Filed under Environment

Skeptoid #112
August 5, 2008
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Today we're going to look at one of the most divisive issues in global food production: genetically modified organisms. Supporters point to vastly improved crop yields and reduced need for fertilizers and pesticides; opponents claim that such products are inadequately tested and may result in unknown dangers. Some poor developing countries, like the Philippines and some African nations, have become battlegrounds between the environmentalists and the farmers. Let's find out what both sides are claiming.

So what exactly are genetically modified organisms, and how does genetic engineering differ from the type of artificial crop development that man has been practicing for thousands of years? Nature's method of genetically hybridizing plants is cross pollination, and for most of human history, this is how farmers and scientists have created new and improved species of crops. Plants can be hybridized quite readily, more so than animals, but there's still a limit to how far apart the species can be. The principal differentiator of direct genetic manipulation is that you can move individual genes from one species to virtually any other species, no matter how different they are. But more to the point, you can select specific genes that carry specifically desirable traits, and accomplish far more significant improvements with much greater control in much less time.

The first commercially available genetically modified organisms were in medicine. The first widely produced GMO was synthetic insulin, which was approved by the FDA in 1982, and is how all medical insulin is now produced. Human growth hormone used to have to be taken from cadavers, but through GMO it's now produced synthetically. The vaccine for Hepatitis B was developed through GMO in 1987. Genetic engineering is also responsible for the oil-eating bacteria used in industrial applications. When designing improved food crops through traditional hybridization, one of the principle barriers is that the new offspring are often sterile, particularly when the species being cross pollinated are too far apart. Through GMO hybridization, this barrier can often be overcome.

When it comes to food crops, the idea is to take the strengths of one plant strain, such as an immunity to a certain disease or a hardiness to certain adverse conditions, and transfer that strength to another plant strain that needs it. One example that researchers are working on now is immunity to the "rust fungus", a fungus that affects all cereals but for some reason rice is immune to it. If that immunity can be given to other cereals like wheat and barley, then we have a better crop that is resistant to one more disease. Yields go up, and the need for chemicals to eradicate the fungus goes down. Everyone wins.

In 1943, what became known as the Green Revolution began when Mexico, unable to feed its growing population, shouted for help. Within a few years, the Ford and Rockefeller Foundations founded the International Rice Research Institute in Asia, and by 1962, a new strain of rice called IR8 was feeding people all over the world. IR8 was the first really big modified crop to make a real impact on world hunger. In 1962 the technology did not yet exist to directly manipulate the genes of plants, and so IR8 was created by carefully crossing existing varieties: selecting the best from each generation, further modifying them, and finally finding the best. Here is the power of modified crops: IR8, with no fertilizer, straight out of the box, produced five times the yield of traditional rice varieties. In optimal conditions with nitrogen, it produced ten times the yield of traditional varieties. By 1980, IR36 resisted pests and grew fast enough to allow two crops a year instead of just one, doubling the yield. And by 1990, using more advanced genetic manipulation techniques, IR72 was outperforming even IR36. The Green Revolution saw worldwide crop yields explode from 1960 through 2000.

No discussion of GMO is complete without a mention of Norman Borlaug, the 1970 Nobel Peace Prize winner, 1977 US Presidential Medal of Freedom winner, 2006 Congressional Gold Medal winner, and best known as the father of the Green Revolution. The unanimous act of Congress states "Dr. Borlaug has saved more lives than any other person who has ever lived, and likely has saved more lives in the Islamic world than any other human being in history." The Nobel committee put a number on this, estimating that he was personally and directly responsible for saving over one billion human beings in the Third World from starvation. Dr. Borlaug did it by pioneering the use of hybrid and genetically modified crops, designing new strains that could thrive in arid conditions where pesticides or herbicides were not available. He's also known for "Borlaug's Hypothesis" which proposes that the best way to reduce deforestation is to reduce demand for new farmland by using our best existing farmland to its maximum potential.

GMO crops also give seed manufacturers capabilities with potential to be less benevolent. By employing what are called "Terminator" genes, manufacturers can theoretically exercise patent enforcement techniques not too different from software activation. You can grow the plants fine, but the engineered traits require chemical activation, thus enforcing annual license fees from farmers. However, terminator features can also be used to address the concerns of anti-GMO activists worried about cross pollination and contamination. Crops can be engineered to produce sterile seeds, or to produce only sterile offspring should cross pollination with conventional crops occur.

When we turn our skeptical eye toward the Philippines, we see Greenpeace activists wearing full biohazard spacesuits cutting down GMO crops and disposing of them in sealed containers. By inviting reporters and photographers to document these demonstrations, they very effectively spread terror among the undereducated poor Filipino public. Now, I think any reasonable person agrees that you wouldn't do such a drastic thing without very good reason; so there must indeed be very good evidence that GMO crops are only safely handled by hazmat disposal teams — wouldn't you think? Let's look at Greenpeace's website and see what frightening information they've uncovered.

The production of unexpected toxins and allergens. Because genetic engineering is a very imprecise technology, the insertion of foreign genes can stimulate the production of unexpected proteins, which may prove toxic or allergenic.

First of all, it's hardly a "very imprecise technology"; gene manipulation requires great precision, and produces far more precisely designed results than can be hoped for with simple cross pollination. The very purpose of the research is to avoid toxic or allergenic results. When these results are found in GMOs, those products are not sent to the market. Duh.

A large part of science involves learning how to make things better. Do we stop all scientific research in every field because learning how to make things better also teaches us what makes them worse? What a ridiculous objection.

Antibiotic resistance. Scientists add genes that confer resistance to common antibiotics.

What they meant to say is that some GMO research seeks to find ways to make crops resistant to harmful bacteria, by incorporating the right toxins into the crop, thus eliminating the need to apply that toxin separately in the form of synthetic or organic pesticides (yes, people, organic pesticides contain the same toxins found in synthetic pesticides — they have to, otherwise they wouldn't function). Finding ways to manage this process to avoid creating resistant pests has been a major area of study in farming science for centuries. This is a farming problem that exists independently of GMO. GMO neither creates nor exacerbates this issue.

Effects on the Environment. Genetically engineered crops represent new and potentially invasive forms of life.

All plant species are potentially invasive, and that's why farmers use good management techniques. There's no reason you should be expected to do this any more or any less with GMO crops as you have always had to do with all crops. This criticism says nothing about GMO.

Contamination of seeds and crops. People are still increasingly finding even non-GE stocks contaminated. This is due to cross pollination where contaminated pollen is carried by wind or as seeds spread out in the environment or are mixed up during handling.

This has always been true of all plants. Cross pollination has nothing to do with GMO. It is responsible for all the biodiversity of plant life on the planet. Calling it "contamination" is simply using a weasel word to raise alarm about a perfectly natural, normal process.

GE foods remove consumer choice. Because of the widespread contamination caused by GE crops and the fact that many GE crops are not kept separate in the food system, consumers in the Philippines have been denied the right to choose not to eat genetically engineered food.

Again, this has always been true of all food crops. Virtually all modern food crops — cereals, corn, rice — are the result of human hybridization. Is Greenpeace applying this criticism to all food crops, or only to those developed by for-profit companies? Is this a scientific objection, or an ideological objection?

Biopiracy. In order to achieve the desired traits chemical companies often use genes acquired from plants, animals and bacteria found in poorer countries. In effect these genes are being stolen from the poor to feed corporate profits.

And what is Greenpeace's most frequent argument in favor of maintaining Brazilian rain forest? The forest, says Greenpeace, acts "as a crucial medicine chest for pharmaceutical advance." When it serves their purposes, Greenpeace is all in favor of using substances from plants in poor countries. But when someone else does it to feed people, suddenly it's "biopiracy". This is the height of hypocrisy. Increasing knowledge by studying genetics in a different country is good for everyone. Is this really the best Greenpeace can do?

Tip Skeptoid $2/mo $5/mo $10/mo One time

Loss of Farmers Rights. Because genetically engineered seeds are patented, the seed company can maintain strict control over how the seeds are used.

This is true of all patented products in the world. Even Greenpeace retains strict control over their legally protected properties, profiting from T-shirt and bumper sticker sales, and prosecuting those who violate their copyrights. This is yet another hypocritical and irrelevant argument that has nothing to do with the science or safety of GMO.

Genetic engineering is unnatural. Because genetic engineering creates new living organisms that would never naturally occur, many people hold moral and spiritual objections to it.

Finally, an honest and factual objection. There's nothing at all wrong with having moral and spiritual opinions. What is wrong is calling them science, and using them to deny food to poor people to whom your spiritual notions may not be as important as feeding their starving children.

And yet, these are the best reasons Greenpeace can come up with to defend the act of terrorizing Filipinos by raiding their farms wearing hazmat suits. I'll conclude my discussion of GMO with a quote from Norman Borlaug, who says it better than I could:

"Some of the environmental lobbyists of the Western nations are the salt of the earth, but many of them are elitists. They've never experienced the physical sensation of hunger. They do their lobbying from comfortable office suites in Washington or Brussels. If they lived just one month amid the misery of the developing world, as I have for fifty years, they'd be crying out for tractors and fertilizer and irrigation canals and be outraged that fashionable elitists back home were trying to deny them these things."

Well said.

Brian Dunning

© 2008 Skeptoid Media, Inc. Copyright information

References & Further Reading

Bennett, P.M., Livesey, C.T., Nathwani, D., Reeves, D.S., Saunders, J.R., Wise, R. "An assessment of the risks associated with the use of antibiotic resistance genes in genetically modified plants: report of the Working Party of the British Society for Antimicrobial Chemotherapy." Journal of Antimicrobial Chemotherapy. 1 Mar. 2004, Volume 53, Issue 3: 418-431.

Dionio, A. "Genetic Engineering Victory in Mindoro." Greenpeace SEAsia. Greenpeace, 12 Oct. 2005. Web. 3 Apr. 2008. <http://www.greenpeace.org/seasia/en/press/reports/ge_victory_mindoro>

Ganzel, Bill. "The Development of "Miracle Rice" Varieties." Living History Farm. Wessels Living History Farm, 1 Jan. 2007. Web. 1 Aug. 2008. <http://www.livinghistoryfarm.org/farminginthe50s/crops_17.html>

NBHF. "Dr. Borlaug's Boyhood Home." The Norman Borlaug Heritage Foundation. The Norman Borlaug Heritage Foundation, 23 May 2008. Web. 23 May. 2008. <http://www.normanborlaug.org/>

Tribe, D. "With scientists on both sides of the GMO debate, how can you know who’s wrong or right?" Biology Fortified. Biology Fortified, Inc., 18 Dec. 2013. Web. 1 Mar. 2014. <http://www.biofortified.org/2013/12/with-scientists-on-both-sides-of-the-gmo-debate-how-can-you-know-whos-wrong-or-right/>

Ward, S.,Byrne P. "'Terminator' Technology." Transgenic Crops:An Introduction and Resource Guide. Department of Soil and Crop Sciences at Colorado State University, 2 Feb. 2004. Web. 28 May. 2008. <http://cls.casa.colostate.edu/TransgenicCrops/terminator.html>

Reference this article:
Dunning, B. "Genetically Modified Organisms: Jeopardy or Jackpot?" Skeptoid Podcast. Skeptoid Media, Inc., 5 Aug 2008. Web. 28 Nov 2014. <http://skeptoid.com/episodes/4112>

Discuss!

10 most recent comments | Show all 168 comments

Mark - So you started eating healthier foods and felt better? Not really shocked. That doesn't mean that GMO was causing your problems. It means that you were focused on better nutrition.

GMO foods don't have any more or less nutrition than their counterparts. A cow eating GMO corn grows the same as a cow eating non GMO corn.

The rat tumor study you cited, BTW, was inherently flawed. The rat strain was already heavily predisposed to getting tumors so one group was bound to have issues. Second the correlations didn't even add up. Groups getting 11% GMO had more tumors than groups getting 33% GMO.

The backbone of science is reproducibility. Meaning any one single study isn't evidence of anything. Redo the rat study with an entirely different organization, with different rat strains, and see if the same results happen. And with independent scientists, not those who have been trying to nail down GMO since 1997 and have an obvious agenda.

Carl., Phoenix, AZ
July 10, 2013 12:40pm

I am disappointed with this article because it still seems to be a run of the mill "us against zealous activists" piece. I could really give two craps about Green Peace for that matter, and I am looking for someone who can address this issue: GMO crops are made primarily to fight against crop damaging fungi and insects. For example, scientists spliced bacteria into corn to rid the European corn borer. This GMO is considered safe for human consumption, but there are other insects- other moths and bees for example, who eat from these same plants and succumb to the same fate of the borer. Are we being at the least negligent in not making sure these don't have a more disastrous effect on the overall populations of potentially harmless insects (and other organisms) as well as the ramifications of how their possible reduction or extinction affect us?

Ashanti, Las Vegas, NV
July 25, 2013 2:17pm

Seeds Of Death - Full Movie:
www.youtube.com/watch?v=eUd9rRSLY4A

Freke1, Denmark
August 12, 2013 1:37pm

Thanx Freke for the lookey see..

Its the same here as it is for the blogs; a nice meaty comment would be helpful.

Ashanti brings up a great point; "what about the insect resistant strains of GME (not GMO, nearly everything you eat is GMO) having an effect on non target species?

When one asks these questions, one should ask whether these bugs actually forage exclusively on crops. Clearly they would in certain regions and clearly there is a problem with this.

This is the case with all conventionally grown crops (ie GMO's) being husbanded the way we do.. But pest resistant GME target only the bugs that eat them.

This is a fantastic case for further research in species specific strains.

For example, can we grow a crop that interrupts the starch->protein pump nature of the locust varieties and grow these to overcome shortfalls in locust infected regions?

GME probably has it on test now.

PS.. GME doesnt mean somebody fiddling with a gene and inserting a walrus. It does mean a number of things... even soaking shoots roots and heads on bacterial solutions (like we always have) for experimental outcomes (like we always have).

We dont need morons like green peace (oh! we love coal green peace) to mow down experimental GME because they have communicable early onset male androgyny... Its that or media issues.

Never could tell..

Mantovani Duck, Greenacres by the sea Oz
August 13, 2013 2:46am

I've read that insects eat somewhere around half of all plant type food that humans produce.

Duncan, Sparks, Nevada USA
August 13, 2013 10:36pm

youd be a lot closer saying bacteria and fungi eat about 99% of what we husband.

The 50% figure would be a good assumption except even bad weather years can knock out production for entire states.

The farmers are in a tough business not only fighting nature but hanging onto modalities they are used to.

the reward years are reward years but the tougher years can be a real battle.

Farming isnt just affected by economic activity, bugs, weather and product sales.. they have to be close to psychic to be winners.

Ask a farmer how tough it is. Nothing but admiration for these guys!

Madime Dantefer, Greenacres by the sea Oz
August 14, 2013 12:28am

I'm a big fan of Skeptoid, and of GMOs. However, when I see multiple issues being conflated I feel the need to speak up.

I don't think the science behind GMOs, and it's general practice - both of which are good - Should be conflated with bad and potentially bad Corporate practices, regulation, and legislation.

The discussion behind how the law deals with RoundUp Ready crops, who can grow them, whether or not the farmer whose stock has been effected can be sued, and what not is practically grounds for its own skeptoid.

Bowman v. Monsanto is a pretty recent example that has been utterly mischaracterized by the Greenpeace whakadoo camp - but there's still issues there, and unresolved but germane questions as to how such products function in the real world. Insofar as who can sue who for what. Bowman was an example of someone who was trying to skirt the law and lost. But what about other farmers who aren't malefactors? They also get sued.

It is true that terminator/sterile seeds makes sense in context, but has their ability to cross polinate - and this is only to preclude subsequent law suits by corporations, not vague health concerns - really been addressed and dealt with? I don't know, but I think the answer is no.

Bucky, Buffalo, NY
January 3, 2014 7:23am

HI Brian,

I like your piece, I agree with it, apart from one point: ' "Antibiotic resistance. Scientists add genes that confer resistance to common antibiotics." What they meant to say is that some GMO research seeks to find ways to make crops resistant to harmful bacteria,'

I think what they are aiming at here, probably has nothing to with resistance in plants to bacteria, but with the common use of antibiotic resistance markers (like Ampicillin resistance) in cloning genes and making the proper constructs in cloning vehicles. Sounds scary, but usually the resistance markers used pose no risk to antibiotics used in human medicine, or they are not present at all in the final product (like Golden Rice 2).

Henri Kester, San Diego
February 10, 2014 8:05pm

Mark from Leesburg, let me give you an anecdote of my own.

I'm living proof that GMOs are good for you. I've been eating GMOs my whole life, and I feel great. I'm 125 pounds (perfectly healthy for a woman of 5'7'') and have no health problems. I have no food allergies, never had a headache in my life, and haven't had so much as a cold or flu in years. Meanwhile, my sister, who eats only organic food, suffers from endometriosis.

If you are getting a positive reading from your bullshit meter, that's a good sign. This is why science doesn't place very much weight on personal anecdote. Lay people have a difficult time distinguishing correlation from causation, in the uncontrolled environment of life, with a sample size of one. You said you went to the hospital, so it sounds like you sought medical treatment. Might your recovery be due more to medical science? We wouldn't know without proper controls. In any case, I'm very happy for your recovery.

Cas, Olywa
February 16, 2014 1:33pm

watch "Is Monsanto's Roundup Pesticide Glyphosate Safe?":
https://www.youtube.com/watch?v=EVZK4n82u6w
(it's only 5 min. long)

Freke1, Denmark
November 18, 2014 3:15pm

Make a comment about this episode of Skeptoid (please try to keep it brief & to the point).

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